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When studying gene function, a common approach is to reduce or block gene expression and then analyze the phenotype. For over a decade, RNA interference (RNAi) has been the king in this field. However, the emergence of new technologies, especially C...

A transposon, also known as a transposable element or jumping gene, is a DNA sequence that can change its position within the genome. Sometimes, it creates or reverses mutations that alter the genetic characteristics of cells and the size of the gen...

The RNA polymerase Pol III uniquely transcribes small noncoding RNAs, including 5S rRNAs (type 1), tRNAs (type 2), and a number of other small RNAs (type 3), such as U6 snRNA. Pol III promoters can be divided into three types: type 1 and type 2 and ...

1. DOTA Original Name: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid Molecular Structure: Metals for Chelation: 52Mn, 55Co, 64Cu, 66Ga, 86Y, 89Zr, 152Tb Literature References: 64Cu, 68Ga, 111In, 177Lu Redox Potential: -0.74 (irreversible)...

Based on their structure, detergents can be broadly classified as: Ionic, Zwitterionic and Non-ionic. Ionic detergents contain anionic or cationic head groups and possess a net charge. The size of an ionic detergent micelle is determined by the comb...

Mouse hover on the 'Description' column to view the full text.AbbreviationStands ForAlso Known AsDescription1-Nalβ-(1-Naphthyl)-L-alanine3-(1-Naphthyl)-L-alanineA non-natural amino acid shown to be a useful building block in the synthesis of peptides...

SUMO Protease, also known as Ulp, is a recombinant fragment of ULP1 (Ubl-specific protease 1) from Saccharomyces cerevisiae. It is highly specific for the SUMO protein fusion, recognizing the tertiary structure of SUMO rather than an amino acid. The...

Adeno-associated virus (AAV) is a replication-defective single-stranded DNA virus of the Parvoviridae family. Productive infection of AAV requires the presence of a helper virus, such as adenovirus (Ad) or herpes simplex virus(HSV). AAV has a genome...

Cis-regulatory elements and trans-regulatory elements are two types of DNA segments that have distinct functions in gene regulation. Cis-regulatory elements are located on the same DNA molecule as the gene they regulate. They are typically short DNA...

A series of diseases characterized by pathological changes in tau proteins, including Alzheimer's disease (AD), are classified as tauopathies (tauopathies). Their common feature is the presence of intracellular neurofibrillary tangles (NFTs) made...