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Product Name
Mouse EGFR/HER1/ErbB1 (Fc Tag) recombinant protein
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Description
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
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Protein name
Epidermal growth factor receptor
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Protein short names
WA-2; AI552599; EGFR; RP23-295E4.1; ERBB; ERRB1; ERBB1; ERRP; WA2; NISBD2; 9030024J15RIK; WA5; ERBB-1; HER1; PIG61; MENA
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Uniprot ID
Q01279
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Gene Name
Egfr
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse EGFR (Q01279) (Met 1-Ser 647) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse EGFR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 864 amino acids and has a calculated molecular mass of 96 kDa. As a result of glycosylation, the apparent molecular mass of rmEGFR/Fc monomer is approximately 130 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind human EGF (Cat:501239) in a functional ELISA.
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Validations
Mouse EGFR / HER1 / ErbB1 Protein (Fc Tag) SDS-PAGE
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