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  • Human EGFR/HER1/ErbB1 (His & GST Tag) recombinant protein

Human EGFR/HER1/ErbB1 (His & GST Tag) recombinant protein

Cat.#: 504048

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Special Price 342.0 USD

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Product Information

  • Product Name
    Human EGFR/HER1/ErbB1 (His & GST Tag) recombinant protein
  • Documents
  • Description
    As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
  • Protein name
    Epidermal growth factor receptor
  • Protein short names
    PIG61; MENA; HER1; ERBB-1; 9030024J15RIK; WA5; ERBB1; ERRP; WA2; NISBD2; ERBB; ERRB1; RP23-295E4.1; WA-2; AI552599; EGFR
  • Uniprot ID
    P00533
  • Gene Name
    EGFR; ERBB; ERBB1; HER1
  • Source/Expression Host
    Baculovirus-Insect cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the cytoplasmic domain (Met 668-Ala 1210) of human EGFR (NP_005219) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human EGFR /GST chimera consists of 780 amino acids and has a calculated molecular mass of 89.1 kDa.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    The specific activity was determined to be 105 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate (see Activity Assay Protocol)
  • Validations

    Human EGFR / HER1 / ErbB1 (aa 668-1210) Protein (His & GST Tag) SDS-PAGE

    Human EGFR / HER1 / ErbB1 (aa 668-1210) Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"