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  • Human EGFR/ERBB/ERBB1/HER1 (Fc tag) recombinant protein

Human EGFR/ERBB/ERBB1/HER1 (Fc tag) recombinant protein

Cat.#: 518441

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Product Information

  • Product Name
    Human EGFR/ERBB/ERBB1/HER1 (Fc tag) recombinant protein
  • Documents
  • Description
    EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.
  • Protein name
    epidermal growth factor receptor(EGFR)
  • Protein short names
    ERBB; ERBB1; HER1
  • Uniprot ID
    P00533
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human EGFR/ERBB/ERBB1/HER1 Leu25-Ser645 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human EGFR/ERBB/ERBB1/HER1 (Fc tag) recombinant protein

    Human EGFR/ERBB/ERBB1/HER1 (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"