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  • Human EGFR/ERBB/ERBB1/HER1 (His tag) recombinant protein

Human EGFR/ERBB/ERBB1/HER1 (His tag) recombinant protein

Cat.#: 518680

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Product Information

  • Product Name
    Human EGFR/ERBB/ERBB1/HER1 (His tag) recombinant protein
  • Documents
  • Description
    The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target.
  • Protein name
    epidermal growth factor receptor(EGFR)
  • Protein short names
    ERBB; ERBB1; HER1
  • Uniprot ID
    P00533
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human EGFR/ERBB/ERBB1/HER1 Leu25-Ser645 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human EGFR/ERBB/ERBB1/HER1 (His tag) recombinant protein

    Human EGFR/ERBB/ERBB1/HER1 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"