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  • Human EGFR/HER1/ErbB1 (Fc Tag) recombinant protein

Human EGFR/HER1/ErbB1 (Fc Tag) recombinant protein

Cat.#: 504095

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Special Price 307.5 USD

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Product Information

  • Product Name
    Human EGFR/HER1/ErbB1 (Fc Tag) recombinant protein
  • Documents
  • Description
    As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
  • Protein name
    Epidermal growth factor receptor
  • Protein short names
    HER1; MENA; PIG61; WA5; 9030024J15RIK; ERBB-1; ERRB1; ERBB; WA2; NISBD2; ERBB1; ERRP; EGFR; WA-2; AI552599; RP23-295E4.1
  • Uniprot ID
    P00533
  • Gene Name
    EGFR; ERBB; ERBB1; HER1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Gly 645) of human EGFR (NP_005219) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human EGFR/Fc chimera is a homodimeric protein. The reduced monomer consists of 860 amino acids and has a calculated molecular mass of 95 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA
    . Immobilized recombinant human EGF at 10 μg/ml (100 μl/well) can bind human EGFR with a linear range of 0.64-400 ng/ml.
  • Validations

    Human EGFR / HER1 / ErbB1 Protein (Fc Tag) SDS-PAGE

    Human EGFR / HER1 / ErbB1 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"