Human EGFR/HER1/ErbB1 (His Tag) recombinant protein

Human EGFR/HER1/ErbB1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Epidermal growth factor receptor

PIG61; MENA; HER1; ERBB-1; 9030024J15RIK; WA5; ERBB1; ERRP; WA2; NISBD2; ERRB1; ERBB; RP23-295E4.1; WA-2; AI552599; EGFR

P00533

EGFR; ERBB; ERBB1; HER1

Human Cells

A DNA sequence encoding the extracellular domain (Met 1-Ser 645) of human EGFR (NP_005219) was expressed with a C-terminal polyhistidine tag.

Human

The recombinant human EGF receptor consists of 630 amino acids and has a calculated molecular mass of 69.8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 110 kDa protein in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Measure by its ability to bind with human EGF in a functional ELISA.