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  • Mouse CD86/B7-2 (His & Fc Tag) recombinant protein

Mouse CD86/B7-2 (His & Fc Tag) recombinant protein

Cat.#: 503093

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Product Information

  • Product Name
    Mouse CD86/B7-2 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.
  • Protein name
    T-lymphocyte activation antigen CD86
  • Protein short names
    B7; MGC34413; ETC-1; CLS1; B7-2; CD28L2; TS/A-2; CD28LG2; B70; LY58; MB7; LY-58; CD86; B7.2; MB7-2; LAB72
  • Uniprot ID
    Q549Q9
  • Gene Name
    Cd86
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Glu 245) of mouse CD86 (NP_062261.3) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse CD86/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 470 amino acids and has a predicted molecular mass of 53.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CD86/Fc monomer is approximately 70-80 kDa due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized human CD28 at 20 μg/ml (100 μl/well) can bind mouse CD86 Fc Chimera with a linear ranger of 6.4-160 ng/ml.
  • Validations

    Mouse CD86 / B7-2 Protein (His & Fc Tag) SDS-PAGE

    Mouse CD86 / B7-2 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"