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  • Human CD86/B7-2 (His & Fc Tag) recombinant protein

Human CD86/B7-2 (His & Fc Tag) recombinant protein

Cat.#: 504521

Special Price 342.0 USD

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Product Information

  • Product Name
    Human CD86/B7-2 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.; (Microbial infection) Acts as a receptor for adenovirus subgroup B. {PubMed:16920215}.
  • Protein name
    T-lymphocyte activation antigen CD86
  • Protein short names
    CD28LG2
  • Uniprot ID
    P42081
  • Gene Name
    CD86; CD28LG2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-His 239) of human B7-2 (NP_008820.2) pro-protein was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human B7-2/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 467 amino acids and has a predicted molecular mass of 53.2 kDa. In SDS-PAGE, the apparent molecular mass of rh B7-2/Fc monomer is approximately 80-90 kDa due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind human CD28 in a functional ELISA.
    2. Measured by its ability to induce IL2 secretion by Jurkat human acute T cell leukemia cells.
    The ED50 for this effect is 1-5μg/mL.
  • Validations

    Human CD86 / B7-2 Protein (His & Fc Tag) SDS-PAGE

    Human CD86 / B7-2 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"