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  • Mouse CD86/B7-2 (His Tag) recombinant protein

Mouse CD86/B7-2 (His Tag) recombinant protein

Cat.#: 503611

Special Price 307.5 USD

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Product Information

  • Product Name
    Mouse CD86/B7-2 (His Tag) recombinant protein
  • Documents
  • Description
    CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.
  • Protein name
    T-lymphocyte activation antigen CD86
  • Protein short names
    MB7; B7.2; MB7-2; LAB72; LY-58; CD86; ETC-1; CLS1; B7-2; CD28L2; B7; MGC34413; LY58; TS/A-2; CD28LG2; B70
  • Uniprot ID
    Q549Q9
  • Gene Name
    Cd86
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Glu 245) of mouse CD86 (NP_062261.3) precursor was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse CD86 consists of 233 amino acids after removal of the signal peptide and has a predicted molecular mass of 26.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CD86 is approximately 40-55 kDa due to glycosylation.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized mouse CD86 at 20 μg/ml (100 μl/well) can bind mouse CD28 with a linear ranger of 6.4-800 ng/ml.
  • Validations

    Mouse CD86 / B7-2 Protein (His Tag) SDS-PAGE

    Mouse CD86 / B7-2 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"