Mouse Fas/Apt1/Tnfrsf6 (His tag) recombinant protein

Mouse Fas/Apt1/Tnfrsf6 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Fas (TNF receptor superfamily member 6)(Fas)

Apt1; Tnfrsf6

P25446

Human Cells

A DNA sequence encoding the Mouse Fas/Apt1/Tnfrsf6 Gln22-Arg169 is expressed with a 6His tag at the C-terminus.

Mouse

>95% as determined by SDS-PAGE.