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Product Name
Rat CD95/APO-1/TNFRSF6 (Fc Tag) recombinant protein
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Description
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).
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Protein name
Tumor necrosis factor receptor superfamily member 6
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Protein short names
AI196731; TNFR6; ALPS1A; FAS; APO-1; FASTM; FAS1; APT1; LPR; APO1; CD95; TNFRSF6
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Uniprot ID
Q63199
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Gene Name
Fas; Apt1; Tnfrsf6
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat FAS (NP_631933.2) (Met1-Lys170) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat FAS/Fc is a disulfide-linked homodimer. The reduced monomer comprises 390 amino acids and has a predicted molecular mass of 43.7 kDa. The apparent molecular mass of the protein is approximately 57 and 36 kDa in SDS-PAGE under reducing conditions.
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Purity
(73+25) % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA.
Immobilized human His-FASLG (Cat：10244-H07Y) at 10 μg/ml (100 μl/well) can bind rat FAS-Fc. The EC50 of rat FAS-Fc is 0.22-0.52 μg/ml. -
Validations
Rat FAS / CD95 / APO-1 / TNFRSF6 Protein (Fc Tag) SDS-PAGE
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