Anti-Fas Rabbit antibody

Cat.#: 168770

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-Fas Rabbit antibody
  • Documents
  • Description
    Fas Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human
  • Alternative names
    APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human Fas
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    IHC: 1/50

    ICC/IF: 1/50

    FC: 1/20

  • Validations

    Western blot detection of Fas in Hela,Jurkat cell lysates using Fas Rabbit mAb(1:500 diluted).Predicted band size:38kDa.Observed band size:45kDa.

    Western blot detection of Fas in Hela,Jurkat cell lysates using Fas Rabbit mAb(1:500 diluted).Predicted band size:38kDa.Observed band size:45kDa.

  • Background
    Swiss-Prot Acc.P25445.Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"