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  • Rat SIRP alpha/CD172a (His Tag) recombinant protein

Rat SIRP alpha/CD172a (His Tag) recombinant protein

Cat.#: 500518

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Product Information

  • Product Name
    Rat SIRP alpha/CD172a (His Tag) recombinant protein
  • Documents
  • Description
    Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. May play a role in the release of nitric oxide by macrophages (By similarity).
  • Protein name
    Tyrosine-protein phosphatase non-receptor type substrate 1
  • Protein short names
    MFR; CD172A; P84; SIRP ALPHA; MYD-1; SIRP; SHPS1; RP23-37B4.2; SHP-1; BIT; PTPNS1; AI835480; SHPS-1
  • Uniprot ID
    P97710
  • Gene Name
    Sirpa; Bit; Mfr; Ptpns1; Shps1; Sirp
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat SIRPA (P97710) (Met1-Asn373) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat SIRPA comprises 353 amino acids and predicts a molecular mass of 39 kDa. The apparent molecular mass of the recombinant protein is approximately 63-80 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Rat SIRP alpha / CD172a Protein (His Tag) SDS-PAGE

    Rat SIRP alpha / CD172a Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"