Anti-SIRP alpha Rabbit antibody

Anti-SIRP alpha Rabbit antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SIRP alpha Rabbit monoclonal antibody

WB, FC

Human, Mouse, Rat

BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1 antibody

Rabbit IgG

Antigen: Recombinant protein of human SIRP alpha

Monoclonal

Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.P78324.Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function . Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.