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  • Mouse SIRP alpha/CD172a (His Tag) recombinant protein

Mouse SIRP alpha/CD172a (His Tag) recombinant protein

Cat.#: 502091

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Product Information

  • Product Name
    Mouse SIRP alpha/CD172a (His Tag) recombinant protein
  • Documents
  • Description
    Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).
  • Protein name
    Tyrosine-protein phosphatase non-receptor type substrate 1
  • Protein short names
    SHPS1; SIRP; PTPNS1; BIT; RP23-37B4.2; SHP-1; AI835480; SHPS-1; MFR; P84; CD172A; SIRP ALPHA; MYD-1
  • Uniprot ID
    P97797
  • Gene Name
    Sirpa; Bit; Myd1; Ptpns1; Shps1; Sirp
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of mouse SIRPA (BAA20376.1) (Met 1-Asn 373) was expressed, with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse SIRPA comprises 353 amino acids and has a calculated molecular mass of 39.4 kDa. As a result of glycosylation, the apparent molecular mass of rmSIRPA is approximately 50-70 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized mouse SIRPA-His at 10 μg/ml (100 μl/well) can bind human CD47-Fc (Cat:504230), The EC50 of human CD47-Fc (Cat:504230) is 0.05-0.13 μg/ml.
  • Validations

    Mouse SIRP alpha / CD172a Protein (His Tag) SDS-PAGE

    Mouse SIRP alpha / CD172a Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"