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  • Anti-SIRP alpha/CD172a antibody

Anti-SIRP alpha/CD172a antibody

Cat.#: 105977

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Product Information

  • Product Name
    Anti-SIRP alpha/CD172a antibody
  • Documents
  • Description
    Rabbit monoclonal to SIRP alpha/CD172a
  • Tested applications
    FCM
  • Species reactivity
    Mouse SIRP alpha / CD172a
  • Alternative names
    p84 antibody; AI835480 antibody; Bit antibody; BIT antibody; CD172a antibody; CD172A antibody; MFR antibody; MYD-1 antibody; P84 antibody; P84 antibody; Ptpns1 antibody; PTPNS1 antibody; RP23-37B4.2 antibody; SHP-1 antibody; SHPS1 antibody; SHPS-1 antibody; SIRP antibody; SIRP antibody; SIRP alpha antibody; SIRP alpha antibody; SHP-1 antibody; Bit antibody; SIRP antibody; CD172a antibody; Ptpns1 antibody; SHPS-1 antibody; AI835480 antibody; BIT antibody; MFR antibody; P84 antibody; SIRP antibody; MYD-1 antibody; SHPS1 antibody; CD172A antibody; PTPNS1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIRP alpha / CD172a (rM SIRP alpha / CD172a; BAA20376.1; Met1-Asn373) and conjugated with APC under optimum conditions, the unreacted APC was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    SIRP alpha / CD172a Antibody (APC), Rabbit MAb, Flow Cytometry

    SIRP alpha / CD172a Antibody (APC), Rabbit MAb, Flow Cytometry

    Flow cytometric analysis of Mouse SIRPA(CD172a) expression on BABL/c bone marrow cells. Cells were stained with APC-conjugated anti-Mouse SIRPA(CD172a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

  • Background
    Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
  • References
    • Timms JF. et al., 1999, Curr Biol. 9: 927-30.
    • Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9.
    • Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
    • Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"