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  • Human SIRP alpha/CD172a (His Tag) recombinant protein

Human SIRP alpha/CD172a (His Tag) recombinant protein

Cat.#: 501315

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Product Information

  • Product Name
    Human SIRP alpha/CD172a (His Tag) recombinant protein
  • Documents
  • Description
    Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
  • Protein name
    Tyrosine-protein phosphatase non-receptor type substrate 1
  • Protein short names
    MYD-1; P84; CD172A; SIRP ALPHA; MFR; AI835480; SHPS-1; RP23-37B4.2; SHP-1; PTPNS1; BIT; SIRP; SHPS1
  • Uniprot ID
    P78324
  • Gene Name
    SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human SIRPA (NP_542970.1) extracellular domain (Met 1-Arg 370) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human SIRPA consists of 351 amino acids and predictes a molecular mass of 39 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSIRPA is approximately 45-50 kDa due to glycosylation.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized human SIRPA-His at 10 μg/ml (100 μl/well) can bind human CD47-Fc (Cat:504230), The EC50 of human CD47-Fc (Cat:504230) is 10.1-23.5 ng/ml.
  • Validations

    Human SIRP alpha / CD172a Protein (His Tag) SDS-PAGE

    Human SIRP alpha / CD172a Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"