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  • Cynomolgus B7-DC/PD-L2/CD273 (Fc Tag) recombinant protein

Cynomolgus B7-DC/PD-L2/CD273 (Fc Tag) recombinant protein

Cat.#: 502301

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Product Information

  • Product Name
    Cynomolgus B7-DC/PD-L2/CD273 (Fc Tag) recombinant protein
  • Documents
  • Description
    Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
  • Protein name
    Programmed cell death ligand 2
  • Protein short names
    BA574F11.2; B7-DC; MGC124039; B7DC; BTDC; PD-L2; PDCD1LG2; PDL2; MGC124040; MGC142240; MGC142238; PDCD1L2; CD273; F730015O22RIK
  • Uniprot ID
    A4GW30
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the cynomolgus PDCD1LG2(A4GW30) (Met1-Pro219) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Cynomolgus
  • Molecular weight
    The recombinant cynomolgus PDCD1LG2 is a disulfide-linked homodimer. The reduced monomer comprises 441 amino acids and has a calculated molecular mass of 49.6 KDa. The apparent molecular mass of the protein is approximately 66 KDa respectively in SDS-PAGE.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized human PD1-His (Cat:503606) at 10 μg/ml (100 μl/well) can bind Cynomolgus PDCD1LG2-Fc (Cat:502301), The EC50 of Cynomolgus PDCD1LG2-Fc is 30.0-75.0 ng/ml.
  • Validations

    Cynomolgus B7-DC / PD-L2 / CD273 Protein (Fc Tag) SDS-PAGE

    Cynomolgus B7-DC / PD-L2 / CD273 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"