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  • Mouse Pdcd1lg2/B7dc/Btdc/Cd273/Pdl2 (Fc tag) recombinant protein

Mouse Pdcd1lg2/B7dc/Btdc/Cd273/Pdl2 (Fc tag) recombinant protein

Cat.#: 519939

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Product Information

  • Product Name
    Mouse Pdcd1lg2/B7dc/Btdc/Cd273/Pdl2 (Fc tag) recombinant protein
  • Documents
  • Description
    Programmed cell death 1 ligand 2 (PD-L2), also known as butyrophilin B7-DC or PDCD1 ligand 2, belongs to the member of B7 family which can regulate the activation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1), and the other is PD-L1. These two ligands shares 34% aa sequence identity. Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide, a 201 aa extracellular region , a 21 aa transmembrane domain and a 32 aa cytoplasmic region. The mouse PD-L2 gene is highly expressed in heart, placenta, pancreas, lung and liver while expressed weakly in spleen, lymph nodes and thymus. Besides, the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment, and up-regulated by IFNG/IFN-gamma stimulation in monocytes. PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expression of PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.
  • Protein name
    programmed cell death 1 ligand 2(Pdcd1lg2)
  • Protein short names
    B7dc; Btdc; Cd273; Pdl2
  • Uniprot ID
    Q9WUL5
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Pdcd1lg2/B7dc/Btdc/Cd273/Pdl2 Leu20-Arg219 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Pdcd1lg2/B7dc/Btdc/Cd273/Pdl2 (Fc tag) recombinant protein

    Mouse Pdcd1lg2/B7dc/Btdc/Cd273/Pdl2 (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"