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  • Mouse Ephrin-A5/EFNA5 (His Tag) recombinant protein

Mouse Ephrin-A5/EFNA5 (His Tag) recombinant protein

Cat.#: 503820

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Product Information

  • Product Name
    Mouse Ephrin-A5/EFNA5 (His Tag) recombinant protein
  • Documents
  • Description
    Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
  • Protein name
    Ephrin-A5
  • Protein short names
    EFL5; EFNA5; EPL7; RAGS; AL-1; LERK-7; EPHRIN-A5; GLC1M; AV158822; LERK7; EFL-5; AF1; EPLG7
  • Uniprot ID
    O08543
  • Gene Name
    Efna5; Epl7; Eplg7; Lerk7
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse EFNA5 isoform long (O08543-1) without the pro peptide (Met 1-Asn 203) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse EFNA5 consists of 194 amino acids and has a predicted molecular mass of 22.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNA5 is approximately 28 kDa due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized Mouse EPHA5 at 2 μg/ml (100 μl/well) can bind mouse EFNA4 with a linear ranger of 1.28-32 ng/ml.
  • Validations

    Mouse Ephrin-A5 / EFNA5 Protein (His Tag) SDS-PAGE

    Mouse Ephrin-A5 / EFNA5 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"