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  • Rhesus Ephrin-A5/EFNA5 (Fc Tag) recombinant protein

Rhesus Ephrin-A5/EFNA5 (Fc Tag) recombinant protein

Cat.#: 503339

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Product Information

  • Product Name
    Rhesus Ephrin-A5/EFNA5 (Fc Tag) recombinant protein
  • Documents
  • Description
    Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
  • Protein name
    EPH-related receptor tyrosine kinase ligand 7
  • Protein short names
    EPLG7; AF1; EFL-5; AV158822; LERK7; EPHRIN-A5; GLC1M; LERK-7; EPL7; RAGS; AL-1; EFNA5; EFL5
  • Uniprot ID
    F7GZC7
  • Gene Name
    EFNA5; EGK_16736
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rhesus EFNA5 (NP_001252657.1) (Met 1-Asn 203) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rhesus
  • Molecular weight
    The recombinant rhesus EFNA5 consists of 424 amino acids and has a calculated molecular mass of 48.2 kDa.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized Rhesus EFNA5-Fc (Cat:503339) at 10 μg/mL (100 μl/well) can bind biotinylated Rhesus EPHA4 (Cat:504687). The EC50 of biotinylated Rhesus EPHA4 (Cat:504687) is 9.3-21.6 ng/mL.
  • Validations

    Cynomolgus Ephrin-A5 / EFNA5 Protein (Fc Tag) SDS-PAGE

    Cynomolgus Ephrin-A5 / EFNA5 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"