Rhesus Ephrin-A5/EFNA5 (Fc Tag) recombinant protein

Rhesus Ephrin-A5/EFNA5 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

EPH-related receptor tyrosine kinase ligand 7

EPLG7; AF1; EFL-5; AV158822; LERK7; EPHRIN-A5; GLC1M; LERK-7; EPL7; RAGS; AL-1; EFNA5; EFL5

F7GZC7

EFNA5; EGK_16736

Human Cells

A DNA sequence encoding the rhesus EFNA5 (NP_001252657.1) (Met 1-Asn 203) was fused with the Fc region of human IgG1 at the C-terminus.

Rhesus

The recombinant rhesus EFNA5 consists of 424 amino acids and has a calculated molecular mass of 48.2 kDa.

> 92 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
Immobilized Rhesus EFNA5-Fc (Cat:503339) at 10 μg/mL (100 μl/well) can bind biotinylated Rhesus EPHA4 (Cat:504687). The EC₅₀ of biotinylated Rhesus EPHA4 (Cat:504687) is 9.3-21.6 ng/mL.