Mouse Ephrin-A5/EFNA5 (Fc Tag) recombinant protein
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
Protein short names
AF1; EFL-5; EPLG7; EPL7; AL-1; RAGS; EFL5; EFNA5; LERK7; AV158822; LERK-7; EPHRIN-A5; GLC1M
Efna5; Epl7; Eplg7; Lerk7
A DNA sequence encoding the mouse EFNA5 isoform long (O08543-1) without the pro peptide (Met 1-Asn 203) was as fused with the Fc region of human IgG1 at the C-terminus.
The recombinant mouse EFNA5/Fc is a disulfide-linked homodimer. The reduced monomer consists of 424 amino acids and has a predicted molecular mass of 48.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNA5/Fc monomer is approximately 52 kDa due to glycosylation.
> 85 % as determined by SDS-PAGE
Measured by its binding ability in a functional ELISA. Immobilized Mouse EPHA4 at 2 μg/ml (100 μl/well) can bind mouse EFNA5-Fc with a linear ranger of 1.28-32 ng/ml.
Mouse Ephrin-A5 / EFNA5 Protein (Fc Tag) SDS-PAGE
Related Products / Services
- Recombinant Proteins
- cDNA Clones
- Human Ephrin-A5/EFNA5 (His Tag) recombinant protein$70.1
- Rhesus Ephrin-A5/EFNA5 (His Tag) recombinant protein$166.9
- Rat Ephrin-A5/EFNA5 (Fc Tag) recombinant protein$191.1
- Rhesus Ephrin-A5/EFNA5 (Fc Tag) recombinant protein$166.9
- Rat Ephrin-A5/EFNA5 (His Tag) recombinant protein$215.3
- Mouse Ephrin-A5/EFNA5 (His Tag) recombinant protein$70.1
- Human EFNA5/EPLG7/LERK7 (Fc tag) recombinant protein$101.2
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"