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  • Mouse Ephrin-A5/EFNA5 (Fc Tag) recombinant protein

Mouse Ephrin-A5/EFNA5 (Fc Tag) recombinant protein

Cat.#: 502960

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Product Information

  • Product Name
    Mouse Ephrin-A5/EFNA5 (Fc Tag) recombinant protein
  • Documents
  • Description
    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
  • Protein name
    Ephrin-A5
  • Protein short names
    AF1; EFL-5; EPLG7; EPL7; AL-1; RAGS; EFL5; EFNA5; LERK7; AV158822; LERK-7; EPHRIN-A5; GLC1M
  • Uniprot ID
    O08543
  • Gene Name
    Efna5; Epl7; Eplg7; Lerk7
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse EFNA5 isoform long (O08543-1) without the pro peptide (Met 1-Asn 203) was as fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse EFNA5/Fc is a disulfide-linked homodimer. The reduced monomer consists of 424 amino acids and has a predicted molecular mass of 48.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNA5/Fc monomer is approximately 52 kDa due to glycosylation.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized Mouse EPHA4 at 2 μg/ml (100 μl/well) can bind mouse EFNA5-Fc with a linear ranger of 1.28-32 ng/ml.
  • Validations

    Mouse Ephrin-A5 / EFNA5 Protein (Fc Tag) SDS-PAGE

    Mouse Ephrin-A5 / EFNA5 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"