Rhesus Ephrin-A5/EFNA5 (His Tag) recombinant protein

Rhesus Ephrin-A5/EFNA5 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

EPH-related receptor tyrosine kinase ligand 7

EFNA5; EFL5; EPL7; AL-1; RAGS; EPHRIN-A5; GLC1M; LERK-7; LERK7; AV158822; EPLG7; AF1; EFL-5

F7GZC7

EFNA5; EGK_16736

Human Cells

A DNA sequence encoding the rhesus EFNA5 (NP_001252657.1) (Met1-Asn203) was expressed, fused with a polyhistidine tag at the C-terminus.

Rhesus

The recombinant rhesus EFNA5 comprises 194 amino acids and has a calculated molecular mass of 22.6 KDa.

> 90 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
Immobilized Rhesus EFNA5-His at 10 μg/ml (100 μl/well) can bind Rhesus EFNA5-His (Cat:504687), The EC₅₀ of Rhesus EFNA5-His (Cat:504687) is 14.8-34.7 ng/ml.