-
Product Name
Mouse HER3/ErbB3 (His Tag) recombinant protein
- Documents
-
Description
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
-
Protein name
Receptor tyrosine-protein kinase erbB-3
-
Protein short names
HER3; P180-ERBB3; C76256; ERBB3-S; LCCS2; MGC88033; ERBB3R; ERBB-3; ERBB3; P45-SERBB3; MGC117742; P85-SERBB3; MDA-BF-1; C-ERBB3; C-ERBB-3
-
Uniprot ID
Q61526
-
Gene Name
Erbb3
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the mouse ERBB3 (Q61526) extracellular domain (Met 1-His 641) was expressed, with a C-terminal polyhistidine tag.
-
Protein Species
Mouse
-
Molecular weight
The secreted recombinant mouse ERBB3 comprises 633 amino acids and has a calculated molecular mass of 70 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 95 kDa in SDS-PAGE under reducing conditions.
-
Purity
> 93 % as determined by SDS-PAGE
-
Activity
Measured by its binding ability in a functional ELISA.
1. Immobilized mouse ErbB3-His (Cat: 500901) at 10 μg/ml (100 μl/well) can bind biotinylated human NRG1 (isoform Beta1) (Cat: 503891) with a linear range of 0.018-0.125 μg/ml.
2. Immobilized mouse ErbB3-His (Cat: 500901) at 10 μg/ml (100 μl/well) can bind biotinylated human NRG1 (aa 2-246)-Fc (Cat: 11609-H04) with a linear range of 6.25-100 ng/ml. -
Validations
Mouse HER3 / ErbB3 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"