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  • Mouse Ctla4/Cd152 (His tag) recombinant protein

Mouse Ctla4/Cd152 (His tag) recombinant protein

Cat.#: 518475

Special Price 127.2 USD

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Product Information

  • Product Name
    Mouse Ctla4/Cd152 (His tag) recombinant protein
  • Documents
  • Description
    Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
  • Protein name
    cytotoxic T-lymphocyte-associated protein 4(Ctla4)
  • Protein short names
    Cd152
  • Uniprot ID
    P09793
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Ctla4/Cd152 Ala37-Asp161 is expressed fused with a 6His tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Ctla4/Cd152 (His tag) recombinant protein

    Mouse Ctla4/Cd152 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"