Human CTLA4 recombinant protein (Native)

Human CTLA4 recombinant protein (Native)

• DataSheet
• Material Safety Data Sheets (MSDS)

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Immune Checkpoint
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IP Antibodies Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins CTLA4 / CD152 Immune Checkpoint Proteins
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy

Cytotoxic T-lymphocyte protein 4

ALPS5,CD,CD152,CELIAC3,CTLA-4,GRD4,GSE,IDDM12

P16410

Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD antigen CD152

Human Cells

A DNA sequence encoding the human CTLA4 (NP_005205.2) (Met1-Asp161) was expressed.

Human

The recombinant human CTLA4 consists of 126 amino acids and predicts a molecular mass of 13.5 kDa.

> 95 % as determined by SDS-PAGE.