Human CTLA-4/CD152 (His & Fc Tag) recombinant protein

Cat.#: 501712

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Product Information

  • Product Name
    Human CTLA-4/CD152 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
  • Protein name
    Cytotoxic T-lymphocyte protein 4
  • Protein short names
    CH29-120A16.2; ICOS; ALPS5; CTLA4; CD; LY-56; CTLA-4; CD152; CELIAC3; GRD4; IDDM12; GSE
  • Uniprot ID
    P16410
  • Gene Name
    CTLA4; CD152
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CTLA4 (NP_005205.2) extracellular domain (Met 1-Phe 162) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CTLA4/Fc is a disulfide-linked homodimer. The reduced monomer consists of 374 amino acids and has a predicted molecular mass of 41.6 kDa. As a result of glycosylation, the apparent molecular mass of rh CTLA4/Fc monomer is approximately 50-55 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Validations

    Human CTLA4 / CD152 Protein (His & Fc Tag) SDS-PAGE

    Human CTLA4 / CD152 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"