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Product Name
Human NAP-2 / PPBP / CXCL7 (His Tag) recombinant protein
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Description
Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.
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Protein name
Platelet basic protein
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Protein short names
NEUTROPHIL ACTIVATING PEPTIDE-2; TC1; RATTUS NORVEGICUS; LDGF; PLATELET BASIC PROTEIN; NAP-2-L1; CHEMOKINE (C-X-C MOTIF) LIGAND 7; CTAP-III; PBP; TC2; CTAP3; MDGF; THBGB; B-TG1; BETA-TG; 2400003M24RIK; AI854500; CTAPIII; THBGB1; NAP-2; CXCL7; TGB1; LA-PF4; TGB; SCYB7
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Uniprot ID
P02775
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Gene Name
PPBP; CTAP3; CXCL7; SCYB7; TGB1; THBGB1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human CXCL7 (P02775) (Ala59-Asp128) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CXCL7 consists of 88 amino acids and predicts a molecular mass of 9.9 KDa. It migrates as an approximately 13 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human NAP-2 / PPBP / CXCL7 Protein (His Tag) SDS-PAGE
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