Cynomolgus NAP-2 / PPBP / CXCL7 (Fc Tag) recombinant protein

Cynomolgus NAP-2 / PPBP / CXCL7 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

C-X-C motif chemokine

TGB1; LA-PF4; SCYB7; TGB; NAP-2; CXCL7; THBGB1; MDGF; CTAP3; THBGB; B-TG1; 2400003M24RIK; CTAPIII; AI854500; BETA-TG; TC2; LDGF; PLATELET BASIC PROTEIN; PBP; CTAP-III; CHEMOKINE (C-X-C MOTIF) LIGAND 7; NAP-2-L1; RATTUS NORVEGICUS; NEUTROPHIL ACTIVATING PEPTIDE-2; TC1

F6SCP6

PPBP; EGK_15792

Human Cells

A DNA sequence encoding the cynomolgus PPBP (F6SCP6) (Thr59-Asp128) was expressed fused with the Fc region of mouse IgG1 at the N-terminus.

Cynomolgus

The recombinant cynomolgus PPBP is a disulfide-linked homodimer. The reduced monomer comprises 306 amino acids and has a calculated molecular mass of 34.3 KDa.The apparent molecular mass of it is approximately 38 KDa respectively in SDS-PAGE.

> 90 % as determined by SDS-PAGE