Rat NAP-2 / PPBP / CXCL7 (Fc Tag) recombinant protein

Rat NAP-2 / PPBP / CXCL7 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

CXC chemokine RTCK1

NEUTROPHIL ACTIVATING PEPTIDE-2; TC1; RATTUS NORVEGICUS; LDGF; PLATELET BASIC PROTEIN; NAP-2-L1; CHEMOKINE (C-X-C MOTIF) LIGAND 7; PBP; CTAP-III; TC2; CTAP3; MDGF; THBGB; B-TG1; BETA-TG; 2400003M24RIK; AI854500; CTAPIII; THBGB1; NAP-2; CXCL7; TGB1; LA-PF4; SCYB7; TGB

Q99ME0

Ppbp; Cxcl7; Rtck1; rCG_60428

Human Cells

A DNA sequence encoding the rat PPBP (NP_714943.1) (Ile 46-Ile 107) was fused with the Fc region of human IgG1 at the N-terminus.

Rat

The recombinant rat PPBP /Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 322 amino acids and has a calculated molecular mass of 35.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rat PPBP /Fc monomer is approximately 40 kDa.

> 95 % as determined by SDS-PAGE