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Human TIGIT/VSTM3 (His Tag) recombinant protein

Cat.#: 500999

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Product Information

  • Product Name
    Human TIGIT/VSTM3 (His Tag) recombinant protein
  • Documents
  • Description
    Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
  • Protein name
    T-cell immunoreceptor with Ig and ITIM domains
  • Protein short names
    WUCAM; DKFZP667A205; FLJ39873; VSTM3; VSIG9; TIGIT; ENSMUSG00000071552
  • Uniprot ID
    Q495A1
  • Gene Name
    TIGIT; VSIG9; VSTM3
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human TIGIT (NP_776160.2) (Met 1-Phe 138) with a C-terminal polyhistidine tag was expressed.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human TIGIT comprises 128 amino acids with a predicted molecular mass of 14.2 kDa.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind with human CD155-Fc (Cat:504524) in a functional ELISA.
    2. Measured by its ability to bind with mouse PVR-Fch (Cat:504218) in a functional ELISA.
  • Validations

    Human TIGIT / VSTM3 Protein (His Tag) SDS-PAGE

    Human TIGIT / VSTM3 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"