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  • Human TIGIT/VSIG9/VSTM3 (Fc tag) recombinant protein

Human TIGIT/VSIG9/VSTM3 (Fc tag) recombinant protein

Cat.#: 518178

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Product Information

  • Product Name
    Human TIGIT/VSIG9/VSTM3 (Fc tag) recombinant protein
  • Documents
  • Description
    T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1.
  • Protein name
    T-cell immunoreceptor with Ig and ITIM domains(TIGIT)
  • Protein short names
    VSIG9; VSTM3
  • Uniprot ID
    Q495A1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human TIGIT/VSIG9/VSTM3 Met22-Pro141 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human TIGIT/VSIG9/VSTM3 (Fc tag) recombinant protein

    Human TIGIT/VSIG9/VSTM3 (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"