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  • Rhesus SELP / P Selectin (Fc Tag) recombinant protein

Rhesus SELP / P Selectin (Fc Tag) recombinant protein

Cat.#: 504438

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Product Information

  • Product Name
    Rhesus SELP / P Selectin (Fc Tag) recombinant protein
  • Documents
  • Description
    P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interacton of activated endothelial cells or platelets with leukocytes.
  • Protein short names
    LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 3; LECAM3; PADGEM; GRMP; RP1-86F14.2; GMP-140; GRANULE MEMBRANE PROTEIN 140; CD62P; GMP140; PLATELET ACTIVATION DEPENDENT GRANULE-EXTERNAL MEMBRANE PROTEIN; CD62 ANTIGEN-LIKE FAMILY MEMBER P; PSEL; CD62; P-SELECTIN
  • Uniprot ID
    F7H811
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rhesus SELP (XP_001094728.1) (Met1-Ala771) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rhesus
  • Molecular weight
    The recombinant rhesus SELP consists of 971 amino acids and predicts a molecular mass of 106.8 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Rhesus SELP / P Selectin Protein (Fc Tag)

    Rhesus SELP / P Selectin Protein (Fc Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"