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Product Name
Mouse SELP / P Selectin (Fc Tag) recombinant protein
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Description
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
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Protein name
P-selectin
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Protein short names
CD62; P-SELECTIN; PSEL; CD62 ANTIGEN-LIKE FAMILY MEMBER P; PLATELET ACTIVATION DEPENDENT GRANULE-EXTERNAL MEMBRANE PROTEIN; GMP140; CD62P; GRANULE MEMBRANE PROTEIN 140; GMP-140; RP1-86F14.2; PADGEM; GRMP; LECAM3; LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 3
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Uniprot ID
Q01102
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Gene Name
Selp; Grmp
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse SELP (NP_035477.1) (Met1-Ala709) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse SELP comprises 909 amino acids and has a predicted molecular mass of 99.6 kDa. The apparent molecular mass of the protein is approximately 134.5 kDa in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Activity
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 10E4 cells/well are added to mouse SELP/Fc Chimera coated plates (10 μg/mL with 100 μL/well), > 60% cells will adhere for 1 hour incubation at 37℃.
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Validations
Mouse SELP / selectin P / P-selectin Protein (Fc Tag) SDS-PAGE
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