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  • Rhesus CD122 / IL-2RB (Fc Tag) recombinant protein

Rhesus CD122 / IL-2RB (Fc Tag) recombinant protein

Cat.#: 504476

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Product Information

  • Product Name
    Rhesus CD122 / IL-2RB (Fc Tag) recombinant protein
  • Documents
  • Description
    Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.
  • Protein short names
    IL2RB; IL-15RBETA; IL15RBETA; IL-2/15RBETA; P70; IL-2RBETA; IL-2RB; CD122; RP5-1170K4.6; P70-75; IL15RB
  • Uniprot ID
    F7GSZ4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rhesus IL2RB (NP_001244989.1) (Met1-Asp239) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rhesus
  • Molecular weight
    The recombinant rhesus IL2RB consists of 451 amino acids and predicts a molecular mass of 51.4 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Rhesus CD122 / IL-2RB Protein (Fc Tag)

    Rhesus CD122 / IL-2RB Protein (Fc Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"