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Product Name
Mouse Cd300a/Clm8/Lmir1/Mcpir1 (Fc tag) recombinant protein
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Description
LMIR1, also termed CD300a, is a type I transmembrane glycoprotein with a single IgV-like extracellular domain and an extended membrane proximal region that links the immunoglobulin (Ig) and transmembrane domains and belongs to the immunoglobulin superfamily. The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs). When cross-linked, it will be tyrosine phosphorylated and capable of recruiting tyrosine phosphatases (SHP-1, SHP-2) and inositol polyphosphate 5-phosphatase, SHIP. LMIR1 will regulate mast cell-mediated inflammatory responses. LMIR1 is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type.
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Protein name
CD300A molecule(Cd300a)
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Protein short names
Clm8; Lmir1; Mcpir1
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Uniprot ID
Q6SJQ0
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Mouse Cd300a/Clm8/Lmir1/Mcpir1 Leu28-Arg183 is expressed with a Fc tag at the C-terminus.
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Protein Species
Mouse
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Purity
>95% as determined by SDS-PAGE.
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Validations
Mouse Cd300a/Clm8/Lmir1/Mcpir1 (Fc tag) recombinant protein
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