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Product Name
Mouse Acvrl1/Acvrlk1/Alk-1 (Fc tag) recombinant protein
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Description
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.
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Protein name
activin A receptor, type II-like 1(Acvrl1)
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Protein short names
Acvrlk1; Alk-1
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Uniprot ID
Q61288
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Mouse Acvrl1/Acvrlk1/Alk-1 Asp23-Pro119 is expressed with a Fc tag at the C-terminus.
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Protein Species
Mouse
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Purity
>95% as determined by SDS-PAGE.
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Validations
Mouse Acvrl1/Acvrlk1/Alk-1 (Fc tag) recombinant protein
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