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Product Name
Cynomolgus ALK-1 / ACVRL1 (His Tag) recombinant protein
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Description
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
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Protein short names
MGC91691; ALK-1; SETHKIR; HHT2; ACVRLK1; HHT; ORW2; ALK1; SKR3; R3; TSR-I; ACVRL1; AI115505; R-3; AI427544
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Uniprot ID
F7HG73
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus ACVRL1 (XP_005570958.1) (Met1-Gln118) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus ACVRL1 consists 108 amino acids and predicts a molecular mass of 12.2 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Cynomolgus ALK-1 / ACVRL1 Protein (His Tag)
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