Human TNFRSF10B/DR5/KILLER (Fc & His tag) recombinant protein

Cat.#: 519322

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Product Information

  • Product Name
    Human TNFRSF10B/DR5/KILLER (Fc & His tag) recombinant protein
  • Documents
  • Description
    TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
  • Protein name
    TNF receptor superfamily member 10b(TNFRSF10B)
  • Protein short names
    DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; UNQ160; PRO186
  • Uniprot ID
    O14763
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human TNFRSF10B/DR5/KILLER Ile56-Glu182 is expressed with a Fc, 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human TNFRSF10B/DR5/KILLER (Fc & His tag) recombinant protein

    Human TNFRSF10B/DR5/KILLER (Fc & His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"