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  • Human PCSK9/NARC1/PSEC0052 (His tag) recombinant protein

Human PCSK9/NARC1/PSEC0052 (His tag) recombinant protein

Cat.#: 519953

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Product Information

  • Product Name
    Human PCSK9/NARC1/PSEC0052 (His tag) recombinant protein
  • Documents
  • Description
    Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (D374Y) is a gain of function mutant of human PCSK9 protein. Human PCSK9 is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain are secreted together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and it plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
  • Protein name
    proprotein convertase subtilisin/kexin type 9(PCSK9)
  • Protein short names
    NARC1; PSEC0052
  • Uniprot ID
    Q8NBP7
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human PCSK9/NARC1/PSEC0052 Gln31-Gln692 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human PCSK9/NARC1/PSEC0052 (His tag) recombinant protein

    Human PCSK9/NARC1/PSEC0052 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"