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Product Name
Human MIF/GLIF/MMIF recombinant protein
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Description
Human MIF is a 12.5 kDa, 115 amino acid (aa) nonglycosylated polypeptide that is synthesized without asignal sequence .Secretion occurs nonclassically via an ABCA1 transporter.Pro-inflammatory cytokine.Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites ofinflammation suggests a role as mediator in regulating the function of acrophages in host defense.Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase anddopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clearwhether the tautomerase activity has any physiological relevance, and whether it is important for cytokineactivity.
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Protein name
macrophage migration inhibitory factor (glycosylation-inhibiting factor)(MIF)
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Protein short names
GLIF; MMIF
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Uniprot ID
P14174
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human MIF/GLIF/MMIF Met1-Ala115 is expressed.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human MIF/GLIF/MMIF recombinant protein
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