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Product Name
Human MIF (His Tag) recombinant protein
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Description
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
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Protein name
Macrophage migration inhibitory factor
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Protein short names
MIF; DER6; GLIF; MMIF; GIF; MGC107654
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Uniprot ID
P14174
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Gene Name
MIF; GLIF; MMIF
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human MIF (P14174) (Pro 2-Ala 115) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human MIF consists of 125 amino acids and has a predicted molecular mass of 13.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhMIF is approximately 19 kDa due to glycosylation.
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Purity
> 92 % as determined by SDS-PAGE
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Validations
Human MIF / GLIF Protein (His Tag) SDS-PAGE
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