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  • Human LIN28 Recombinant protein (His tag)

Human LIN28 Recombinant protein (His tag)

Cat.#: 509533

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Product Information

  • Product Name
    Human LIN28 Recombinant protein (His tag)
  • Documents
  • Description
    'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs (PubMed:19703396) (PubMed:22118463) (PubMed:22898984). Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (By similarity). {, PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984}.
  • Protein name
    Protein lin-28 homolog A
  • Protein short names
    CSDD1; LIN28; ZCCHC1
  • Uniprot ID
    Q9H9Z2
  • Gene Name
    LIN28A; CSDD1; LIN28; ZCCHC1
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    1-209 aa encoded by BC028566 was inserted into PET28a vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human LIN28(Full length) SDS-PAGE

    Recombinant human LIN28(Full length) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"