Human LIN28 Recombinant protein (His tag)

Human LIN28 Recombinant protein (His tag)

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'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs (PubMed:19703396) (PubMed:22118463) (PubMed:22898984). Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (By similarity). {, PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984}.

Protein lin-28 homolog A

CSDD1; LIN28; ZCCHC1

Q9H9Z2

LIN28A; CSDD1; LIN28; ZCCHC1

E. coli

A DNA sequence encoding the human LIN28A (XP_054194727.1) 1-209 aa was fused with the polyhistidine tag

Human

Not tested.