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Product Name
Anti-LIN28A (2C1) Mouse antibody
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Description
LIN28A (2C1) Mouse monoclonal antibody
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Tested applications
WB
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Species reactivity
Human, Mouse
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Alternative names
CSDD1;FLJ12457;LIN 28;Lin-28A;LIN28;LIN28A;LN28A_HUMAN;Protein lin-28 homolog A;ZCCHC1; Zinc finger CCHC domain-containing protein 1. antibody
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Isotype
IgG2a
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Preparation
Antigen: Purified recombinant human LIN28A protein fragments expressed in E.coli
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Clonality
Monoclonal
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Formulation
Purified mouse monoclonal in PBS(pH 7.4)containing with 0.02% sodium azide and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
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Validations
Western blot detection of LIN28 in NTERA and F9 cell lysates using LIN28A mouse mAb (1:1000 diluted).Predicted band size:26KDa.Observed band size:26KDa.
Western blot detection of LIN28A in LIN28B and LIN28A recombinant antigen fragments and using LIN28A mouse mAb (1:1000 diluted).
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Background
Swiss-Prot Acc.Q9H9Z2.Involved in the timing of developmental events and choice of stage specific cell fates. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7.
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References
- Primordial Dwarfism Gene Maintains Lin28 Expression to Safeguard Embryonic Stem Cells from Premature Differentiation
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"