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Product Name
Human ITPA/C20orf37/My049/OK/SW-cl.9 (His tag) recombinant protein
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Description
Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.
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Protein name
inosine triphosphatase(ITPA)
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Protein short names
C20orf37; My049; OK; SW-cl.9
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Uniprot ID
Q9BY32
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human ITPA/C20orf37/My049/OK/SW-cl.9 Ala2-Ala194 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human ITPA/C20orf37/My049/OK/SW-cl.9 (His tag) recombinant protein
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