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  • Human IL13 / ALRH (Fc Tag) recombinant protein

Human IL13 / ALRH (Fc Tag) recombinant protein

Cat.#: 503572

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Product Information

  • Product Name
    Human IL13 / ALRH (Fc Tag) recombinant protein
  • Documents
  • Description
    Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.
  • Protein name
    Interleukin-13
  • Protein short names
    MGC116788; IL-13; MGC116786; ALRH; P600; BHR1; MGC116789
  • Uniprot ID
    P35225
  • Gene Name
    IL13; NC30
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of human IL13 (AAK53823.1) (Gly 21-Asn 132) was fused with the Fc region of human IgG1 at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human Fc/IL13 chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 349 amino acids and predicts a molecular mass of 39 kDa. The apparent molecular mass of rhIL13/Fc monomer is approximately 50-55 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL13RA2 at 8 μg/ml (100 μl/well) can bind IL13 with a linear range of 0.25-8.0 ng/ml.
  • Validations

    Human IL13 / ALRH Protein (Fc Tag) SDS-PAGE

    Human IL13 / ALRH Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"