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Product Name
Mouse Il13/Il-13 recombinant protein
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Description
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.
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Protein name
interleukin 13(Il13)
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Protein short names
Il-13
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Uniprot ID
P20109
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Mouse Il13/Il-13 Ser26-Phe131 is expressed.
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Protein Species
Mouse
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Purity
>95% as determined by SDS-PAGE.
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Validations
Mouse Il13/Il-13 recombinant protein
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