Human CXCL1 (His & SUMO Tag) recombinant protein

Cat.#: 503571

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Product Information

  • Product Name
    Human CXCL1 (His & SUMO Tag) recombinant protein
  • Documents
  • Description
    The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.
  • Protein name
    Growth-regulated alpha protein
  • Protein short names
    GRO1; GRO; CXCL1; KC; SCYB1; GROA; MGSA-A; N51; MGSA; FSP; NAP-3
  • Uniprot ID
    P09341
  • Gene Name
    CXCL1; GRO; GRO1; GROA; MGSA; SCYB1
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of human CXCL1 (P09341-1) (Ala 35-Asn 107) was fused with a N-terminal polyhistide-tagged SUMO tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CXCL1 consisting of 189 amino acids and has a calculated molecular mass of 21.3 kDa. It migrates as an 30 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Validations

    Human CXCL1 / MGSA / NAP-3 Protein (His & SUMO Tag) SDS-PAGE

    Human CXCL1 / MGSA / NAP-3 Protein (His & SUMO Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"