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Product Name
Human CXCL1 recombinant protein
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Description
The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.
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Protein name
Growth-regulated alpha protein
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Protein short names
GRO1; GRO; CXCL1; KC; SCYB1; GROA; MGSA-A; N51; MGSA; FSP; NAP-3
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Uniprot ID
P09341
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Gene Name
CXCL1; GRO; GRO1; GROA; MGSA; SCYB1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human CXCL1 (P09341-1) (Ala35-Asn107) was expressed.
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Protein Species
Human
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Molecular weight
The recombinant human CXCL1 consists of 73 amino acids and predicts a molecular mass of 7.9 kDa. It migrates as an approximately 7-10 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human CXCL1 / MGSA / NAP-3 Protein SDS-PAGE
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"